Strathmore has been a uranium company since 1996. Its goal is to become a leading uranium producer in the United States. The Company's uranium property acquisition strategy was initiated when the uranium price was between US $7-15 per lb. Strathmore was successful in acquiring advanced uranium projects in the two largest historical uranium producing regions in the United States: the Gas Hills Uranium District in Wyoming and the Grants Mineral District in New Mexico. Many of these projects were extensively explored and advanced to the mine planning stage, but were later abandoned due to prolonged weak uranium prices. In 2005, Strathmore opened operations offices in Riverton Wyoming and Santa Fe, New Mexico. Projects were reviewed and prioritized, and permitting efforts were initiated.

Strathmore is advancing two core uranium development projects towards production: the Gas Hills in Wyoming, and Roca Honda in New Mexico. In 2007, Roca Honda was joint ventured with Sumitomo Corp of Japan. In 2009, the Joint Venture submitted its Roca Honda mine permit application, which was deemed "administratively complete" by the regulatory agencies, and is now undergoing technical review. Roca Honda represents the largest proposed uranium mine in the United States in over thirty years.